LATEST RESEARCH: Bisphenol A (BPA) Causes 100 x More Harm Than Previously Imagined

July 21, 2015 by  
Filed under Health Blog

A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound

 

Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical, and one of the major new issues is the safe replacement of this commonly used compound.

Bisphenol S (BPS) and bisphenol F (BPF) are already or are planned to be used as BPA alternatives. With the use of a culture system that we developed (fetal testis assay [FeTA]), we previously showed that 10 nmol/L BPA reduces basal testosterone secretion of human fetal testis explants and that the susceptibility to BPA is at least 100-fold lower in rat and mouse fetal testes.

Here, we show that addition of LH in the FeTA system considerably enhances BPA minimum effective concentration in mouse and human but not in rat fetal testes. Then, using the FeTA system without LH (the experimental conditions in which mouse and human fetal testes are most sensitive to BPA), we found that, as for BPA, 10 nmol/L BPS or BPF is sufficient to decrease basal testosterone secretion by human fetal testes with often nonmonotonic dose-response curves.

In fetal mouse testes, the dose-response curves were mostly monotonic and the minimum effective concentrations were 1,000 nmol/L for BPA and BPF and 100 nmol/L for BPS. Finally, 10,000 nmol/L BPA, BPS, or BPF reduced Insl3 expression in cultured mouse fetal testes.

This is the first report describing BPS and BPF adverse effects on a physiologic function in humans and rodents.

Research article here: http://www.fertstert.org/article/S0015-0282(14)02351-6/fulltext

 

Yours In Great Health,
Sar Rooney BHSc., ND., DC., DASc., GDSc. (Hons), MATMS, MHATO
Naturopathic Medicine practitioner, Lecturer, Researcher
 

Specializing in Anxiety & Depression | Women’s Health | Chronic Fatigue | Natural Hormone Therapy | Thyroid Disorders | Digestive Health | Autoimmune Disease | Genetic Polymorphisms (MTHFR, Pyroluria) & Nutrigenomics  | Nutritional Medicine | Counselling | Optimal Wellness & Disease Prevention with a Clinical Focus on Identifying & Resolving the Underlying Causes of Symptoms and Disease. 

Earth Medicine TM
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Disclaimer: The information provided is not intended to replace medical advice or treatment. Please note: I am not a medical practitioner.

 

 

 

 

 

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