ALZHEIMER’S MAY ORIGINATE IN A FORM SIMILAR TO THAT OF INFECTIOUS PRION DISEASES

October 10, 2011 by  
Filed under Health Blog

The following extract was taken from an article published in the News Medical (4.10.11) Source: University of Texas Health Science Center at Houston:

“The brain damage that characterizes Alzheimer’s disease may originate in a form similar to that of infectious prion diseases such as bovine spongiform encephalopathy (mad cow) and Creutzfeldt-Jakob, according to newly published research by The University of Texas Health Science Center at Houston (UTHealth).  “Our findings open the possibility that some of the sporadic Alzheimer’s cases may arise from an infectious process, which occurs with other neurological diseases such as mad cow and its human form, “Creutzfeldt-Jakob disease” said Claudio Soto, Ph.D., professor of neurology at The University of Texas Medical School at Houston, part of UTHealth. “The underlying mechanism of Alzheimer’s disease is very similar to the prion diseases. It involves a normal protein that becomes misshapen and is able to spread by transforming good proteins to bad ones. The bad proteins accumulate in the brain, forming plaque deposits that are believed to kill neuron cells in Alzheimer’s.”  The results showing a potentially infectious spreading of Alzheimer’s disease in animal models were published in the Oct. 4, 2011 online issue of Molecular Psychiatry, part of the Nature Publishing Group. The research was funded by The George P. and Cynthia W. Mitchell Center for Research in Alzheimer’s Disease and Related Brain Disorders at UTHealth.
Alzheimer’s disease is a form of progressive dementia that affects memory, thinking and behavior. Of the estimated 5.4 million cases of Alzheimer’s in the United States, 90 percent are sporadic. The plaques caused by misshapen aggregates of beta amyloid protein, along with twisted fibers of the protein tau, are the two major hallmarks associated with the disease. Alzheimer’s is the sixth leading cause of death in the United States, according to the Alzheimer’s Association.  Researchers injected the brain tissue of a confirmed Alzheimer’s patient into mice and compared the results to those from injected tissue of a control without the disease. None of the mice injected with the control showed signs of Alzheimer’s, whereas all of those injected with Alzheimer’s brain extracts developed plaques and other brain alterations typical of the disease.  “We took a normal mouse model that spontaneously does not develop any brain damage and injected a small amount of Alzheimer’s human brain tissue into the animal’s brain,” said Soto, who is director of the Mitchell Center. “The mouse developed Alzheimer’s over time and it spread to other portions of the brain. We are currently working on whether disease transmission can happen in real life under more natural routes of exposure.”

Sar’s comments: If this research is found to be on the right track, I wonder if becoming a vegetarian will prevent Alzheimer’s? Maybe that’s some of the further research that needs to be carried out – i.e. A control study in humans of meat eaters and vegetarians affected by Alzheimer’s and the resulting statistics.

Does anyone know a vegetarian that developed Alzheimer’s because in 18 years of clinical practice I have never met one? Do you work in a nursing home or know someone who does? If so, perhaps you could ask them this question. Food for thought!

Yours In Great Health,

Sar Rooney BHSc., ND., DC., DASc., GDSc. (Hons), MATMS, MNHAA, MHATO

Naturopathic Medicine Practitioner, Lecturer, Researcher

 

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